Project 13

Behavioural characterisation of ephrin-A2/ephrin-A5 double knockout mice: vision and memory

The project addresses the role of Eph/ephrin interactions in the development of visual system connectivity and their contribution to remodelling synaptic connections in the adult during learning and memory. There is considerable evidence that Eph/ephrin interactions play an important role in both processes. Double knockout mice for two key members of the ephrin-A family, ephrin-A2 and ephrin-A5 provides an exceptional model in which to carry out behavioural studies.

The honours project will develop a selection of the following tests, depending on the area of interest of the student. Learning and memory (radial arm maze); Visual function (visual acuity, optokinetic response, orienting behaviour, light entrainment of circadian rhythms). Behavioural analysis will be supported by appropriate anatomical and/or physiological techniques.

The project will involve working closely with the animal care unit (maintaining breeding records) and regular genotyping of the animals.