Project 14

Axon regeneration induced by genetically modified Schwann cells

Using lentiviral vectors it is possible to introduce growth factor genes into adult Schwann cells. We have shown previously that these genetically modified cells can be incorporated into peripheral nerve sheaths and, when grafted onto the injured optic nerve, they promote increased regeneration of adult retinal ganglion cell (RGC) axons (Hu et al., Molecular Therapy, 2005). In this project we will examine whether similar types of graft also promote the regeneration of RGC axons when the injury occurs in the brain, at a significant distance from the eye. The study address a critical issue in neural repair - the extent to which the site of axon injury affects the regenerative capability of an injured nerve cell.